The distribution of acid and alkaline ribonuclease activities in preneoplastic and neoplastic rat livers. | Zendy

S M Murthy | Zendy; R. Daoust | Zendy

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The distribution of acid and alkaline ribonuclease activities in preneoplastic and neoplastic rat livers.

Author(s) -

S M Murthy,

R. Daoust

Publication year - 1977

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/25.2.14209

Subject(s) - rnase p , ribonuclease , substrate (aquarium) , precipitation , chemistry , biochemistry , microbiology and biotechnology , rna , biology , ecology , physics , meteorology , gene

Ribonuclease (RNase) activities revealed by the substrate film method were compared with reactions for acid and alkaline RNase obtained by lead precipitation technique in serial sections of preneoplastic livers and hepatomas. The preneoplastic parenchymal tissue giving positive reactions with ribonucleic acid films showed both acid and alkaline RNase activities by lead precipitation technique, and the area of hyperplastic nodules nonreactive against substrate films were deficient in acid and alkaline RNase activities. Preneoplastic hyperbasophilic foci and hepatoma gave weak or negative reactions by either method, but necrotic areas and stromal tissue showed appreciable RNase activities. Thus a good correlation was observed in these tissues between the RNase activities revealed by the film method and those demonstrated by lead precipitation.

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