Aldose reductase and sorbitol dehydrogenase distribution in rat kidney. | Zendy

Clinton N. Corder | Zendy; J. Grant Collins | Zendy; T. Brannan | Zendy; Jyotsna Sharma | Zendy

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Aldose reductase and sorbitol dehydrogenase distribution in rat kidney.

Author(s) -

Clinton N. Corder,

J. Grant Collins,

T. Brannan,

Jyotsna Sharma

Publication year - 1977

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/25.1.401844

Subject(s) - aldose reductase , sorbitol dehydrogenase , sorbitol , medicine , endocrinology , kidney , polyol pathway , renal medulla , chemistry , fructose , convoluted tubule , distal convoluted tubule , medulla , biology , diabetes mellitus , biochemistry , nephron

The sorbitol pathway catalyzes the conversion of glucose to fructose via the intermediate sorbitol. It consists of aldose reductase (AR) and sorbitol dehydrogenase (SDH). In adult (44 day) kidney zones, AR was highest in the outer medulla. In substructures AR was highest in distal convoluted tubule. The AR was greatest in newborn and 8-day zones of developing rat kidney. Acute alloxan diabetes was associated with decreased AR in small arteries, but not glomeruli. The SDH was lowest in outer medulla. It was most active in glomeruli and distal convoluted tubules. The diabetic state leads to no change of SDH in arteries but an increase in glomeruli. SDH increased with development. This study demonstrates AR and SDH in substructures of the kidney. The pathway is present in developing kidney. In diabetes the enzymatic changes would tend to decrease accumulation of sorbitol.

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