Aurothiomalate as an ultrastructural marker. Electron microscopy and x-ray microanalysis of various tissues after in vivo gold injections. | Zendy

R. Yarom | Zendy; H Stein | Zendy; Ada Dormann | Zendy; P. D. Peters | Zendy; T. A. Hall | Zendy

Open Access

Aurothiomalate as an ultrastructural marker. Electron microscopy and x-ray microanalysis of various tissues after in vivo gold injections.

Author(s) -

R. Yarom,

H Stein,

Ada Dormann,

P. D. Peters,

T. A. Hall

Publication year - 1976

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/24.2.1254942

Subject(s) - ultrastructure , vacuole , microanalysis , organelle , acid phosphatase , in vivo , electron microscope , pathology , chemistry , electron probe microanalysis , biology , biophysics , cytoplasm , electron microprobe , biochemistry , mineralogy , enzyme , medicine , optics , physics , microbiology and biotechnology , organic chemistry

Rabbits and rats were given single injections of aurothiomalate by different routes. The animals were killed at progressive intervals, and sections from various organs were examined by electron microscopic x-ray microanalysis. Ultrastructurally, characteristic material was regularly found in vacuoles, dense and heterogeneous bodies of macrophages, hepatocytes and renal epithelial cells. Occasionally, other mesenchymal cells also contained gold. Histochemical and analytical tests showed that the gold-containing organelles were devoid of acid phosphatase activity. The generalized rapid spread, retention and selectivity of localization after a single small dose make aurothiomalate a useful marker substance for ultrastructural studies.

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