The effect of different combinations of vascular, dependency and cognitive endpoints on the sample size required to detect a treatment effect in trials of treatments to improve outcome after lacunar and non-lacunar ischaemic stroke | Zendy

Stephen Makin | Zendy; Fergus Doubal | Zendy; Terence J. Quinn | Zendy; Philip M. Bath | Zendy; Martin Dennis | Zendy; Joanna M. Wardlaw | Zendy

Open Access

The effect of different combinations of vascular, dependency and cognitive endpoints on the sample size required to detect a treatment effect in trials of treatments to improve outcome after lacunar and non-lacunar ischaemic stroke

Author(s) -

Stephen Makin,

Fergus Doubal,

Terence J. Quinn,

Philip M. Bath,

Martin Dennis,

Joanna M. Wardlaw

Publication year - 2017

Publication title -

european stroke journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 16

eISSN - 2396-9881

pISSN - 2396-9873

DOI - 10.1177/2396987317728854

Subject(s) - lacunar stroke , medicine , stroke (engine) , dementia , montreal cognitive assessment , cognition , vascular dementia , sample size determination , cardiology , randomized controlled trial , physical therapy , vascular disease , ischemic stroke , ischemia , disease , psychiatry , mechanical engineering , statistics , mathematics , engineering

Endpoints that are commonly used in trials of moderate/severe stroke may be less frequent in patients with minor, non-disabling stroke thus inflating sample sizes. We tested whether trial efficiency might be improved with composite endpoints.

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