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The recent launch of complex artificial intelligence (AI) in the domain of healthcare has embedded perplexities within patients, clinicians, and policymakers. The opaque and complex nature of artificial intelligence makes it challenging for clinicians to interpret its outcome. Incorrect interpretation and poor utilization of AI might hamper patient safety. The principles of human factors and ergonomics (HFE) can assist in simplifying AI design and consecutively optimize human performance ensuring better understanding of AI outcome, their interaction with the clinical workflow. In this paper, we discuss the interactions of providers with AI and how HFE can influence these interacting components to patient safety.

Human factors: bridging artificial intelligence and patient safety