Open AccessSeroprevalence of Anti-SARS-CoV-2 IgG Antibodies among HIV Infected Individuals Attending ART Centre at Pune: A Cross-Sectional Study
Author(s) -
Manisha Ghate,
Pallavi Shidhaye,
Shraddha Gurav,
Keshav Gadhe,
Varsha Kale,
Preeti Jain,
Madhuri Thakar
Publication year - 2022
Publication title -
journal of the international association of providers of aids care
Language(s) - English
Resource type - Journals
eISSN - 2325-9582
pISSN - 2325-9574
DOI - 10.1177/23259582221077943
Subject(s) - seroprevalence , medicine , cross sectional study , antibody , covid-19 , serology , immunology , human immunodeficiency virus (hiv) , virology , disease , infectious disease (medical specialty) , pathology
Background: We aimed to determine the anti-SARS-CoV-2 IgG antibodies among people living with HIV (PLHIV) in Pune, India. Methods: This cross-sectional study was conducted between March 2021 and June 2021. Demographic and clinical information related to coronavirus disease 2019 (COVID-19) were recorded on structured questionnaires. Blood samples were collected and tested for anti-SARS-CoV-2 IgG antibodies using commercial ELISA. Results: Of the 405 HIV infected individuals enrolled in the study, 223(55.1%) were females. Mean age and CD4 count of participants were 42 years (SD: 10) and 626 cells/mm 3 (SD: 284) respectively. A total of 382 (95%) PLHIV were virologically suppressed. The seropositivity against SARS-CoV-2 was found in 221 PLHIV (54.6%, 95% CI: 49.7-59.4). No significant association was found between demographic or clinical factors and seropositivity. Conclusion: A high prevalence of anti-SARS-CoV-2 IgG antibodies was found among PLHIV attending ART centre indicating an exposure to the virus among them.