Rapid Diagnosis of Invasive Aspergillosis and Active Hepatitis-B Virus Co-Infection in a HIV-1 Infected Patient Using Cell Free DNA Sequencing | Zendy

Moni Roy | Zendy; Joseph Y. Kim | Zendy; Rone-Chun Lin | Zendy

Open Access

Rapid Diagnosis of Invasive Aspergillosis and Active Hepatitis-B Virus Co-Infection in a HIV-1 Infected Patient Using Cell Free DNA Sequencing

Author(s) -

Moni Roy,

Joseph Y. Kim,

Rone-Chun Lin

Publication year - 2020

Publication title -

journal of the international association of providers of aids care (jiapac)

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.813

H-Index - 31

eISSN - 2325-9582

pISSN - 2325-9574

DOI - 10.1177/2325958220976263

Subject(s) - medicine , aspergillosis , virology , hepatitis b virus , human immunodeficiency virus (hiv) , virus , immunology , cell free fetal dna , biology , genetics , pregnancy , fetus , prenatal diagnosis

Multiple simultaneous opportunistic infections in Human Immunodeficiency virus-1/Acquired immunodeficiency syndrome (HIV-1/AIDS) is a known and dreaded occurrence that often leads to poor outcomes. We present a case of disseminated aspergillosis and active Hepatitis-B virus (HBV) infection in such a host, where cell free DNA (cfDNA) next generation sequencing (NGS) of plasma was used to expedite diagnosis. Bronchoscopy was avoided and treatment was started expeditiously. In this case report we discuss the interpretation of the cfDNA NGS, and its potential role for early diagnosis and avoidance of invasive testing.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research