The distribution of collagenase in normal rat tissues. | Zendy

I Montfort | Zendy; Ruy Pérez-Tamayo | Zendy

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The distribution of collagenase in normal rat tissues.

Author(s) -

I Montfort,

Ruy Pérez-Tamayo

Publication year - 1975

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/23.12.172556

Subject(s) - collagenase , connective tissue , uterus , spleen , kidney , pathology , immunohistochemistry , antibody , staining , biology , interstitial collagenase , microbial collagenase , chemistry , anatomy , endocrinology , enzyme , medicine , immunology , biochemistry

A rabbit monospecific anti-rat uterus collagenase antibody has been used to study the distribution of collagenase in normal rat tissues by immunohistochemical methods. Indirect staining was performed with fluorescein-conjugated goat anti-rabbit immunoglobulin G antibody. The organs studied were brain, lung, myocardium, liver, spleen, kidney, adrenal, testes, uterus, xiphoid cartilage, tail tendon, skeletal (triceps) muscle and skin. Collagenase is widely present throughout the connective tissue structures in all organs examined. The enzyme is apparently bound to collagen fibers, reticulum fibers and basement membranes. The results suggest that control of collagenase activity depends on factors other than the presence of the enzyme in tissues.

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