Rosai-dorfman disease of the fibula: A case report | Zendy

Purnomo Glen | Zendy; Dueñas Jesus Adrian A | Zendy; Rotor Richard S | Zendy; Claudio Rafael S | Zendy

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Rosai-dorfman disease of the fibula: A case report

Author(s) -

Purnomo Glen,

Dueñas Jesus Adrian A,

Rotor Richard S,

Claudio Rafael S

Publication year - 2019

Publication title -

journal of orthopaedics, trauma and rehabilitation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.167

H-Index - 6

eISSN - 2210-4925

pISSN - 2210-4917

DOI - 10.1177/2210491719842950

Subject(s) - leukocytosis , rosai–dorfman disease , medicine , presentation (obstetrics) , cervical lymphadenopathy , fibula , cd68 , pathology , biopsy , disease , sinus histiocytosis with massive lymphadenopathy , cervical lymph nodes , immunohistochemistry , surgery , metastasis , tibia , cancer

Rosai–Dorfman disease (RDD) is usually characterized by painless bilateral cervical lymphadenopathy associated with fever and leukocytosis. Although the disease may occur outside lymphnodes, manifestation of skeletal system occurs in less than 8% of cases. In addition, presentation of this disease in a purely skeletal form without lymph nodes involvement is extremely uncommon. This case report describes a 17-year-old female with a pure skeletal presentation of RDD in the fibula. Trocar biopsy was performed, and immunohistochemical staining using S100 and CD68 was done to confirm the diagnosis.

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