CELL CYCLE ANALYSIS FROM COMPUTER SYNTHESIS OF DEOXYRIBONUCLEIC ACID HISTOGRAMS | Zendy

Joe W. Gray | Zendy

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CELL CYCLE ANALYSIS FROM COMPUTER SYNTHESIS OF DEOXYRIBONUCLEIC ACID HISTOGRAMS

Author(s) -

Joe W. Gray

Publication year - 1974

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/22.7.642

Subject(s) - histogram , dna synthesis , population , dna , cell cycle , dispersion (optics) , cell , biological system , chemistry , biophysics , biology , computer science , biochemistry , physics , optics , medicine , artificial intelligence , image (mathematics) , environmental health

A method is presented for the computer synthesis of deoxyribonucleic acid (DNA) histograms, based on estimates of cell distribution around a life cycle, DNA synthesis rate and instrumentally introduced dispersion. Synthetic histograms are compared with experimental DNA histograms for two cell systems; in one, the cell population is in asynchronous exponential growth (steady state), in the other, the cell population is recovering from a block at the G 1 /S phase interface (nonsteady state). The average phase transit times and the associated dispersions are determined, using a DNA histogram synthesis technique, for the nonsteady state population.

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