AUTOMATIC RECOGNITION OF IRRADIATED CHROMOSOMES
Author(s) -
Raj Aggarwal,
K. S. Fu
Publication year - 1974
Publication title -
journal of histochemistry and cytochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.971
H-Index - 124
eISSN - 1551-5044
pISSN - 0022-1554
DOI - 10.1177/22.7.561
Subject(s) - mitosis , chromatid , irradiation , biology , cell , microbiology and biotechnology , computational biology , genetics , physics , chromosome , nuclear physics , gene
There are essentially three types of aberrations of irradiated chromosomes in a mitotic cell; namely, fragments, rings and dicentrics, which are resulted from breakages and exchanges of chromatids. The occurrence of any of these aberrations is considered to be a very useful indicator of radiation damage at cell level. The large volume of tests required for monitoring health-related radiation damage necessitates an automated system for recognition of these aberrant chromosomes. Such a system, using a cutoff level independent skeletonization approach, has been developed and is discussed in this paper. The test results on 15 abnormal cells are also presented.
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