PROCION YELLOW M-4RS BINDING TO NEURONAL MEMBRANES | Zendy

Michael T. Flanagan | Zendy; T R Hesketh | Zendy; S-H. CHUNG | Zendy

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PROCION YELLOW M-4RS BINDING TO NEURONAL MEMBRANES

Author(s) -

Michael T. Flanagan,

T R Hesketh,

S-H. CHUNG

Publication year - 1974

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/22.10.952

Subject(s) - membrane , organelle , covalent bond , intracellular , chemistry , fluorescence , nucleic acid , biophysics , biochemistry , subcellular localization , fluorescein , phospholipid , biology , cytoplasm , organic chemistry , physics , quantum mechanics

Procion Yellow M-4RS, an intracellular neuronal marker, has been shown to bind covalently to the subcellular organelles of rat brain under physiologic conditions. Binding to purified proteins, nucleic acids and lipids also occurs under such conditions, the probable site of attachment being the primary amino group. Lipid membranes were highly impermeable to this dye. The fluorescence intensity of Procion Yellow M-4RS was shown to be viscosity-dependent. These results are consistent with the behavior of the dye when it is used for mapping neurons.

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