The cytological mechanism and effects of hypertensive cerebral hemorrhage treatment by citicoline on serum GFAP and copeptin level | Zendy

Zang Jun | Zendy; Liu Ai-xian | Zendy; Qi Lin | Zendy

Open Access

The cytological mechanism and effects of hypertensive cerebral hemorrhage treatment by citicoline on serum GFAP and copeptin level

Author(s) -

Zang Jun,

Liu Ai-xian,

Qi Lin

Publication year - 2019

Publication title -

european journal of inflammation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.219

H-Index - 20

eISSN - 2058-7392

pISSN - 1721-727X

DOI - 10.1177/2058739219867244

Subject(s) - citicoline , intracerebral hemorrhage , glial fibrillary acidic protein , medicine , choline , copeptin , gastroenterology , anesthesia , pharmacology , subarachnoid hemorrhage , immunohistochemistry , vasopressin

In this study, 102 patients with hypertensive intracerebral hemorrhage (52 patients in the citicoline treatment group and 50 patients in the routine treatment group) were analyzed and compared. It was found that citicoline-assisted treatment of hypertensive intracerebral hemorrhage could inhibit the release of serum glial fibrillary acidic protein (GFAP) and peptides ( P < 0.05) and improve the prognosis and neurological and daily living ability of patients ( P < 0.05). In addition, CDP-choline reduced the mortality of neurons, inhibited inflammatory factors, and improved the prognosis of patients ( P < 0.05). A high dose of CDP-choline was also significantly effective in protecting neurons.

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