SATB1 promotes epithelial-mesenchymal transition via Notch signaling pathway in colorectal cancer | Zendy

Tang Jun | Zendy; Yang Jingfang | Zendy

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SATB1 promotes epithelial-mesenchymal transition via Notch signaling pathway in colorectal cancer

Author(s) -

Tang Jun,

Yang Jingfang

Publication year - 2019

Publication title -

european journal of inflammation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.219

H-Index - 20

eISSN - 2058-7392

pISSN - 1721-727X

DOI - 10.1177/2058739219858896

Subject(s) - epithelial–mesenchymal transition , notch signaling pathway , cancer research , colorectal cancer , downregulation and upregulation , gene knockdown , metastasis , signal transduction , cadherin , biology , cancer , cell , microbiology and biotechnology , cell culture , gene , genetics

Epithelial-mesenchymal transition (EMT) is essential for initiation of colorectal cancer (CRC) metastasis, but the diver proteins of EMT remain unclear. Special AT-rich sequence-binding protein 1 (SATB1) was found to be overexpressed in CRC cell lines, and its expression level was positively correlated with CRC progression. Strikingly, EMT process was regulated by SATB1, as SATB1 overexpression upregulated E-cadherin and SATB1 knockdown inhibited N-cadherin cell models. Mechanistically, SATB1 promoted EMT-mediated CRC metastasis via activation of Notch signaling pathway. Taken together, SATB1 plays a vital role in CRC metastasis and may act as a novel prognostic biomarker and a promising therapeutic target for CRC.

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