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Stromal cell–derived factor 1 (SDF-1) and its receptor CXCR4 have shown to play a role in embryonic development process, regulation of hematopoiesis, mediating immunology response, inflammatory reaction, and metastasis of malignant tumor. Recently, SDF-1 and CXCR4 are also closely related to retinal neovascularization. This study was to investigate the expression of SDF-1 and CXCR4 in the retina after optic nerve injury in pregnant rats so as to reveal its significance. A total of 12 pregnant rats were randomly divided into normal group and experimental group (after 5 days of optic nerve injury), six rats in each group; expressions of SDF-1 as well as CXCR4 in rat retina were detected by immunofluorescence staining and western blot assay. The result of immunofluorescence staining showed that the relative gray scale values of SDF-1 and CXCR4 in the experimental group were significantly higher than those in the normal group ( P &lt; 0.05), and the result of Western blot assay showed that the expression levels of SDF-1 and CXCR4 in the experimental group were significantly higher than those in the normal group ( P &lt; 0.05). In conclusion, SDF-1 and its receptor CXCR4 have abnormal expression in the retina of pregnant rats after optic nerve injury, which may be involved in the occurrence and development of optic nerve injury.

Expression and significance of SDF-1 and its receptor CXCR4 in the retina of pregnant rats after optic nerve injury