The protective effects of 18β-glycyrrhetinic acid against inflammation microenvironment in gastric tumorigenesis targeting PGE2-EP2 receptor-mediated arachidonic acid pathway | Zendy

Donghui Cao | Zendy; Jing Jiang | Zendy; Dan Zhao | Zendy; Menghui Wu | Zendy; Zhang Houjun | Zendy; Tianyu Zhou | Zendy; Tetsuya Tsukamoto | Zendy; Masanobu Oshima | Zendy; Quan Wang | Zendy; Xueyuan Cao | Zendy

Open Access

The protective effects of 18β-glycyrrhetinic acid against inflammation microenvironment in gastric tumorigenesis targeting PGE2-EP2 receptor-mediated arachidonic acid pathway

Author(s) -

Donghui Cao,

Jing Jiang,

Dan Zhao,

Menghui Wu,

Zhang Houjun,

Tianyu Zhou,

Tetsuya Tsukamoto,

Masanobu Oshima,

Quan Wang,

Xueyuan Cao

Publication year - 2018

Publication title -

european journal of inflammation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.219

H-Index - 20

eISSN - 2058-7392

pISSN - 1721-727X

DOI - 10.1177/2058739218762993

Subject(s) - inflammation , arachidonic acid , prostaglandin e2 receptor , carcinogenesis , prostaglandin e2 , pharmacology , cyclooxygenase , prostaglandin , in vivo , chemistry , receptor , cancer research , biology , cancer , immunology , medicine , biochemistry , endocrinology , enzyme , microbiology and biotechnology , agonist

Accumulating epidemiological and clinical evidence shows that inflammation is an important risk factor for gastrointestinal diseases. Glycyrrhiza glabra, a traditional Chinese medicine, has been shown to safely suppress gastric cancer; however, the anti-inflammatory mechanisms in gastric tumorigenesis have been poorly investigated. Therefore, this study is committed to demonstrate the in vivo anti-inflammatory effect of 18β-glycyrrhetinic acid (GRA), the main active component of G. glabra. The lymphocytes and macrophages were heavily infiltrated in the transgenic mice that highly expressed cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES)-1; however, a significant reduction was observed after treatment with GRA. In addition, GRA downregulated the protein levels of COX-2, GαS, EP2, and β-catenin, which were involved in the arachidonic acid pathway. In conclusion, our study showed the potential protective effects of GRA against inflammatory environment that might be involved in gastric tumorigenesis in vivo through the PGE2-EP2 receptor-mediated arachidonic acid pathway.

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