Evaluation of seminal fluid leukocyte subpopulations in patients with varicocele | Zendy

Laura M. Mongioì | Zendy; Angela Alamo | Zendy; Aldo E. Calogero | Zendy; Michele Compag | Zendy; Filippo Giacone | Zendy; Rossella Cannarella | Zendy; Sandro La Vignera | Zendy; Rosita A. Condorelli | Zendy

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Evaluation of seminal fluid leukocyte subpopulations in patients with varicocele

Author(s) -

Laura M. Mongioì,

Angela Alamo,

Aldo E. Calogero,

Michele Compag,

Filippo Giacone,

Rossella Cannarella,

Sandro La Vignera,

Rosita A. Condorelli

Publication year - 2020

Publication title -

international journal of immunopathology and pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.724

H-Index - 53

eISSN - 2058-7384

pISSN - 0394-6320

DOI - 10.1177/2058738420925719

Subject(s) - varicocele , sperm , andrology , medicine , flow cytometry , semen , male infertility , urology , infertility , biology , immunology , pregnancy , genetics

Varicocele is a common cause of sperm damage. Some studies showed higher concentration of seminal leukocytes in patients with varicocele. The aim of the study was to evaluate seminal leukocyte subpopulations in patients with varicocele. We enrolled 20 patients with varicocele and 20 age-matched healthy men. Sperm analysis was conducted according to the World Health Organization (WHO) 2010 criteria. We evaluated seminal leukocyte subpopulations and bio-functional sperm parameters by flow cytometry. Patients with varicocele had significantly lower sperm concentration and total number than controls. Regarding seminal leukocyte subpopulations, patients with varicocele had a significantly lower percentage of CD8+ and CD16+ leukocytes and a significantly higher percentage of CD4+ leukocytes than controls. As for bio-functional sperm parameters, we found that patients with varicocele had a significantly lower percentage of alive spermatozoa compared to the control group. These results may explain the increased level of cytokines in the seminal plasma of patients with varicocele.

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