Open AccessASIA syndrome: Adverse reaction or autoimmunity?
Author(s) -
Diogo André,
Fabiana Gouveia,
Rafael Nascimento,
Helena Luís,
Mónica Caldeira,
Caldeira Ferreira,
António José Chaves
Publication year - 2022
Publication title -
jrsm open
Language(s) - English
Resource type - Journals
ISSN - 2054-2704
DOI - 10.1177/20542704221086166
Subject(s) - genetic predisposition , adjuvant , disease , medicine , connective tissue , autoimmunity , connective tissue disease , dermatology , autoimmune disease , silicone , immunology , pathology , chemistry , organic chemistry
Adjuvant-Induced Autoimmune / Auto-inflammatory Syndrome (ASIA) is an immune-mediated condition by the exposure of material previously considered inert, such as silicone, aluminum salts, mineral oils, hyaluronic acid and metallic implants. In addition to a genetic component, there is a risk of development of an undifferentiated connective tissue disease, which varies clinically and laboratorially depending on the adjuvant material used.Patients and methods: This paper addresses two cases reported, in caucasian subjects, born and residents in Madeira Island, Portugal. In this article are described two different histological patterns occurring in ASIA patients, due to mammoplasty with silicone.Conclusion: Although ASIA does not meet the diagnostic requirements for connective tissue disease, there is a close relationship with the development of autoimmune conditions. These cases aim to alert the medical community to the existence of this entity, encourage the notification of situations arising from exposure to adjuvants and investigate the presence of a genetic predisposition and a suggestive histological pattern in excisional biopsies of satellite adenomegalies.