Open AccessTrichloroethylene increases pulmonary endothelial permeability: implication for pulmonary veno‐occlusive disease
Author(s) -
Caliez Julien,
Riou Marianne,
Manaud Grégoire,
Nakhleh Morad K.,
Quatredeniers Marceau,
RuckerMartin Catherine,
Dorfmüller Peter,
Lecerf Florence,
Vinhas Maria C.,
Khatib Salam,
Haick Hossam,
CohenKaminsky Sylvia,
Humbert Marc,
Montani David,
Perros Frédéric
Publication year - 2020
Publication title -
pulmonary circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.791
H-Index - 40
ISSN - 2045-8940
DOI - 10.1177/2045894020907884
Subject(s) - medicine , pulmonary vasculature , trichloroethylene , pulmonary veno occlusive disease , cardiology , vascular permeability , lung , pulmonary disease , pathology , chemistry , environmental chemistry
Trichloroethylene exposure is a major risk factor for pulmonary veno‐occlusive disease. We demonstrated that trichloroethylene alters the endothelial barrier integrity, at least in part, through vascular endothelial (VE)‐Cadherin internalisation, and suggested that this mechanism may play a role in the development of pulmonary veno‐occlusive disease.