Open AccessEnhanced circulating levels of CD3 cells‐derived extracellular vesicles in different forms of pulmonary hypertension
Author(s) -
Kosanovic Djuro,
Deo Ujjwal,
Gall Henning,
Selvakumar Balachandar,
Herold Susanne,
Weiss Astrid,
Petrovic Aleksandar,
Sydykov Akylbek,
Ghofrani Hossein Ardeschir,
Schermuly Ralph Theo
Publication year - 2019
Publication title -
pulmonary circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.791
H-Index - 40
ISSN - 2045-8940
DOI - 10.1177/2045894019864357
Subject(s) - extracellular vesicles , extracellular , pulmonary hypertension , medicine , vesicle , pathological , inflammation , microvesicles , extracellular vesicle , extracellular fluid , microbiology and biotechnology , pulmonary vasculature , immunology , pathology , biochemistry , biology , microrna , membrane , gene
It has been shown previously that increased circulating endothelial cells‐derived extracellular vesicles represent an important pathological attribute of pulmonary hypertension. Although it is a well‐known fact that inflammatory cells may also release extracellular vesicles, and pulmonary hypertension is a disease associated with abnormal inflammation, there is no profound knowledge with regard to the role of inflammatory cells‐derived extracellular vesicles. Therefore, our study demonstrated that circulating levels of extracellular vesicles derived from T‐cells are enhanced in various pulmonary hypertension forms and that endothelial cells‐derived extracellular vesicles may have distinctive profiles in different clinical subgroups of pulmonary hypertension, which still remains as a poorly treatable and life‐threatening disorder.