Open AccessPathophysiology, incidence, management, and consequences of cardiac arrhythmia in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension
Author(s) -
Cirulis Meghan M.,
Ryan John J.,
Archer Stephen L.
Publication year - 2019
Publication title -
pulmonary circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.791
H-Index - 40
ISSN - 2045-8940
DOI - 10.1177/2045894019834890
Subject(s) - medicine , chronic thromboembolic pulmonary hypertension , pulmonary hypertension , pathophysiology , cardiology , incidence (geometry) , epidemiology , intensive care medicine , sudden cardiac death , cardiac arrhythmia , atrial fibrillation , physics , optics
Arrhythmias are increasingly recognized as serious, end‐stage complications of pre‐capillary pulmonary hypertension, including pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). Although arrhythmias contribute to symptoms, morbidity, in‐hospital mortality, and possibly sudden death in PAH/CTEPH, there remains a paucity of epidemiologic, pathophysiologic, and outcome data to guide management of these patients. This review summarizes the most current evidence on the topic: from the molecular mechanisms driving arrhythmia in the hypertrophied or failing right heart, to the clinical aspects of epidemiology, diagnosis, and management.