Open AccessHypoxia‐induced pulmonary vasoconstriction of intra‐acinar arteries is impaired in NADPH oxidase 4 gene‐deficient mice
Author(s) -
Murtaza Ghulam,
Paddenberg Renate,
Pfeil Uwe,
Goldenberg Anna,
Mermer Petra,
Kummer Wolfgang
Publication year - 2018
Publication title -
pulmonary circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.791
H-Index - 40
ISSN - 2045-8940
DOI - 10.1177/2045894018808240
Subject(s) - hypoxic pulmonary vasoconstriction , nox4 , nadph oxidase , medicine , vasoconstriction , hypoxia (environmental) , endocrinology , oxidase test , cardiology , oxygen , enzyme , biochemistry , biology , chemistry , oxidative stress , organic chemistry
We show that genetic deficiency of the reactive oxygen species generating enzyme NADPH oxidase 4 (NOX4) impairs hypoxic pulmonary vasoconstriction in small (25–40 µm) intra‐acinar, but not pre‐acinar, arteries in murine precision cut lung slices. These data suggest an involvement of NOX4 in ventilation‐perfusion matching at the acinar level.