Open AccessUbiquitin chains: a new way of screening for regulatory differences in pulmonary hypertension
Author(s) -
Rathinasabapathy Anandharajan,
West James D.
Publication year - 2018
Publication title -
pulmonary circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.791
H-Index - 40
ISSN - 2045-8940
DOI - 10.1177/2045894018796782
Subject(s) - ubiquitin , medicine , pulmonary hypertension , microbiology and biotechnology , intracellular , innate immune system , ubiquitin ligase , bioinformatics , immunology , biochemistry , biology , gene , immune system
Protein ubiquitination serves many regulatory functions; in addition to degradation, ubiquitination has roles in intracellular trafficking, cell cycle, innate immunity, and more. Using mass spectrometry, it is possible to assess the ubiquitination state of every protein simultaneously. In this issue, Wade et al. have for the first time done just that in a hypoxic mouse model of pulmonary hypertension (PH). New techniques drive new discoveries; their work is important not just because they have found new ways to intervene in known PH-related pathways but have found regulation of proteins not previously associated with disease.