Open AccessImpaired systemic oxygen extraction in treated exercise pulmonary hypertension: a new engine in an old car?
Author(s) -
FariaUrbina Mariana,
Oliveira Rudolf K.F.,
Segrera Sergio A.,
Lawler Laurie,
Waxman Aaron B.,
Systrom David M.
Publication year - 2018
Publication title -
pulmonary circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.791
H-Index - 40
ISSN - 2045-8940
DOI - 10.1177/2045893218755325
Subject(s) - medicine , pulmonary hypertension , hemodynamics , cardiology , ambrisentan , anesthesia , receptor , endothelin receptor , bosentan
Ambrisentan in 22 patients with pulmonary hypertension diagnosed during exercise (ePH) improved pulmonary hemodynamics; however, there was only a trend toward increased maximum oxygen uptake (VO 2 max) secondary to decreased maximum exercise systemic oxygen extraction (Ca‐vO 2 ). We speculate that improved pulmonary hemodynamics at maximum exercise “unmasked” a pre‐existing skeletal muscle abnormality.