Impaired systemic oxygen extraction in treated exercise pulmonary hypertension: a new engine in an old car? | Zendy

FariaUrbina Mariana | Zendy; Oliveira Rudolf K.F. | Zendy; Segrera Sergio A. | Zendy; Lawler Laurie | Zendy; Waxman Aaron B. | Zendy; Systrom David M. | Zendy

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Impaired systemic oxygen extraction in treated exercise pulmonary hypertension: a new engine in an old car?

Author(s) -

FariaUrbina Mariana,

Oliveira Rudolf K.F.,

Segrera Sergio A.,

Lawler Laurie,

Waxman Aaron B.,

Systrom David M.

Publication year - 2018

Publication title -

pulmonary circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.791

H-Index - 40

ISSN - 2045-8940

DOI - 10.1177/2045893218755325

Subject(s) - medicine , pulmonary hypertension , cardiology , oxygen , organic chemistry , chemistry

Ambrisentan in 22 patients with pulmonary hypertension diagnosed during exercise (ePH) improved pulmonary hemodynamics; however, there was only a trend toward increased maximum oxygen uptake (VO 2 max) secondary to decreased maximum exercise systemic oxygen extraction (Ca‐vO 2 ). We speculate that improved pulmonary hemodynamics at maximum exercise “unmasked” a pre‐existing skeletal muscle abnormality.

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