Open AccessSystemic delivery of MicroRNA mimics with polyethylenimine elevates pulmonary microRNA levels, but lacks pulmonary selectivity
Author(s) -
Schlosser Kenny,
Taha Mohamad,
Deng Yupu,
Stewart Duncan J.
Publication year - 2017
Publication title -
pulmonary circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.791
H-Index - 40
ISSN - 2045-8940
DOI - 10.1177/2045893217750613
Subject(s) - polyethylenimine , microrna , medicine , lung , gene delivery , pulmonary hypertension , bioinformatics , genetic enhancement , pharmacology , cardiology , gene , transfection , biology , genetics
Reversing pathologic alterations in vascular microRNA (miRNA) expression represents a potential therapeutic strategy for pulmonary hypertension. While polyethylenimine (PEI) has previously been shown to be an effective vehicle for vascular lung‐directed delivery of plasmid DNA, it remains unclear whether this utility is generalizable to miRNAs. Here we show that despite elevated lung levels, the intravenous infusion of PEI–miRNA mimic complexes fails to provide lung‐selective delivery in rats.