Open AccessRiociguat, a soluble guanylate cyclase stimulator, ameliorates right ventricular contraction in pulmonary arterial hypertension
Author(s) -
Murata Mitsushige,
Kawakami Takashi,
Kataoka Masaharu,
Kohno Takashi,
Itabashi Yuji,
Fukuda Keiichi
Publication year - 2017
Publication title -
pulmonary circulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.791
H-Index - 40
ISSN - 2045-8940
DOI - 10.1177/2045893217746111
Subject(s) - riociguat , medicine , guanylate cyclase , pulmonary hypertension , cardiology , afterload , contraction (grammar) , hemodynamics , chronic thromboembolic pulmonary hypertension , nitric oxide
Riociguat is a soluble guanylate cyclase stimulator used for pulmonary hypertension (PH) treatment. We evaluated right ventricular (RV) contractile function in 27 PH patients receiving riociguat. A comparison of pre‐ and post‐administration echocardiographic studies demonstrated significantly improved RV strain after riociguat treatment, even after adjusting for RV afterload.