Glycated LDL-C and glycated HDL-C in association with adiposity, blood and atherogenicity indices in metabolic syndrome patients with and without prediabetes | Zendy

Rawan Mohammad Al Saudi | Zendy; Violet Kasabri | Zendy; Randa Naffa | Zendy; Nailya Bulatova | Zendy; Yasser Bustanji | Zendy

Open Access

Glycated LDL-C and glycated HDL-C in association with adiposity, blood and atherogenicity indices in metabolic syndrome patients with and without prediabetes

Author(s) -

Rawan Mohammad Al Saudi,

Violet Kasabri,

Randa Naffa,

Nailya Bulatova,

Yasser Bustanji

Publication year - 2018

Publication title -

therapeutic advances in endocrinology and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.889

H-Index - 30

eISSN - 2042-0196

pISSN - 2042-0188

DOI - 10.1177/2042018818788198

Subject(s) - medicine , endocrinology , metabolic syndrome , prediabetes , glycated hemoglobin , type 2 diabetes mellitus , overweight , diabetes mellitus , body mass index , type 2 diabetes , obesity

Background: The aim of the study was to compare and correlate glycated high-density lipoprotein (GHDL-C) and glycated low-density lipoprotein (GLDL-C) plasma levels with adiposity indices [weight/hip ratio (WHR) and body adiposity index (BAI)], lipid ratios and hematological indices [platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR)].Methods: This was a cross-sectional study of 30 nondiabetic metabolic syndrome (MetS) patients, 30 prediabetic or type 2 diabetes mellitus (T2DM) patients and 30 normoglycemic controls.Results: Remarkably both GHDL-C and GLDL-C levels lacked any intergroup statistically significant discrepancy in either MetS or MetS-pre/T2DM versus control ( p > 0.05). Unlike GLDL-C/LDL-C ratios for either MetS groups; there were highly significant intergroup differences in the means of GHDL-C/HDL-C ratios when comparing both nondiabetic MetS and MetS-pre/T2DM groups versus controls ( p = 0.001). In MetS patients; GHDL-C and GLDL-C proportionally correlated with WHR ( p < 0.05). Also, MetS GHDL-C correlated inversely with MLR and monocytes ( p < 0.05). In MetS-pre/T2DM; GLDL-C directly correlated with BAI, platelet count and PLR ( p < 0.05).Conclusion: GLDL-C and GHDL-C are dysfunctional glucolipotoxicity lipoproteins and may present putatively surrogate biomarkers for prediction/prevention of metabolic disturbances.

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