Recurrent acute ischaemic strokes as the primary presentation of Sjögren’s syndrome | Zendy

Raja Ezman Raja Shariff | Zendy; Sazzli Kasim | Zendy

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Recurrent acute ischaemic strokes as the primary presentation of Sjögren’s syndrome

Author(s) -

Raja Ezman Raja Shariff,

Sazzli Kasim

Publication year - 2020

Publication title -

proceedings of singapore healthcare

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.21

H-Index - 9

eISSN - 2059-2329

pISSN - 2010-1058

DOI - 10.1177/2010105820911950

Subject(s) - medicine , vasculitis , presentation (obstetrics) , stroke (engine) , disease , ischaemic stroke , cerebral vasculitis , cerebral infarction , vascular disease , central nervous system , pathology , dermatology , ischemia , surgery , mechanical engineering , engineering

Sjögren’s syndrome (SS) is a multi-systemic autoimmune disease. Central nervous system (CNS) involvement is rare. We report a case of large-vessel vasculitis and cerebral infarction as an initial presentation of SS. Neurological complications in SS is often due to peripheral neuropathy through small-vessel vasculitis. In rare cases, CNS involvement can occur, including acute ischaemic strokes (AIS), linked to both accelerated artherosclerosis and large-vessel vasculitis. Management of SS-related AIS remains complex due to the scarcity of evidence, although a role for immunomodulation and biologics remains promising. Clinicians should remain vigilant in identifying SS as a cause for stroke, especially in the young.

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