THE DESOXYRIBOSE NUCLEIC ACID (DNA) CONTENT OF HUMAN MONOCYTES AND THEIR DERIVATIVES DURING GIANT CELL FORMATION IN VITRO | Zendy

Milton N. Goldstein | Zendy

Open Access

THE DESOXYRIBOSE NUCLEIC ACID (DNA) CONTENT OF HUMAN MONOCYTES AND THEIR DERIVATIVES DURING GIANT CELL FORMATION IN VITRO

Author(s) -

Milton N. Goldstein

Publication year - 1954

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/2.4.274

Subject(s) - nucleic acid , multinucleate , giant cell , dna , feulgen stain , in vitro , cell , cell fusion , ploidy , cell nucleus , chemistry , nuclear dna , microbiology and biotechnology , biology , biochemistry , cytoplasm , genetics , gene , mitochondrial dna

1. The desoxyribose nucleic acid (DNA) content of individual cell nuclei in monocytes and their derivatives, multinucleated giant cells, has been determined by microspectrophotometry. These measurements were performed on Feulgen stained material. 2. Although most of the measurements of individual nuclei in cultures incubated from 4 to 138 hours were close to diploid value, there were variations in some nuclei well above and below this value. 3. The data indicated that DNA was being synthesized during cultivation. 4. Amitosis occurred in some of the nuclei of the multinucleated giant cells after these cells had formed by cell fusion.

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