Distinct Cancer-Specific Survival in Metastatic Prostate Cancer Patients Classified by a Panel of Single Nucleotide Polymorphisms of Cancer-Associated Genes | Zendy

Norihiko Tsuchiya | Zendy; Shimpei Matsui | Zendy; Shintaro Narita | Zendy; Tomomi Kamba | Zendy; Koji Mitsuzuka | Zendy; Shingo Hatakeyama | Zendy; Yohei Horikawa | Zendy; Takamitsu Inoue | Zendy; Seiichi Saito | Zendy; Chikara Οhyama | Zendy; Yoichi Arai | Zendy; Osamu Ogawa | Zendy; Tomonori Habuchi | Zendy

Open Access

Distinct Cancer-Specific Survival in Metastatic Prostate Cancer Patients Classified by a Panel of Single Nucleotide Polymorphisms of Cancer-Associated Genes

Author(s) -

Norihiko Tsuchiya,

Shimpei Matsui,

Shintaro Narita,

Tomomi Kamba,

Koji Mitsuzuka,

Shingo Hatakeyama,

Yohei Horikawa,

Takamitsu Inoue,

Seiichi Saito,

Chikara Οhyama,

Yoichi Arai,

Osamu Ogawa,

Tomonori Habuchi

Publication year - 2013

Publication title -

genes and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.883

H-Index - 71

eISSN - 1947-6027

pISSN - 1947-6019

DOI - 10.1177/1947601913481354

Subject(s) - single nucleotide polymorphism , cancer , snp , prostate cancer , medicine , genotype , oncology , biology , genetics , gene

Individual genetic variations may have a significant influence on the survival of metastatic prostate cancer (PCa) patients. We aimed to identify target genes and their variations involved in the survival of PCa patients using a single nucleotide polymorphism (SNP) panel. A total of 185 PCa patients with bone metastasis at the initial diagnosis were analyzed. Germline DNA in each patient was genotyped using a cancer SNP panel that contained 1,421 SNPs in 408 cancer-related genes. SNPs associated with survival were screened by a log-rank test. Fourteen SNPs in 6 genes, XRCC4, PMS1, GATA3, IL13, CASP8, and IGF1, were identified to have a statistically significant association with cancer-specific survival. The cancer-specific survival times of patients grouped according to the number of risk genotypes of 6 SNPs selected from the 14 SNPs differed significantly (0-1 v. 2-3 v. 4-6 risk genotypes; P = 7.20 × 10(-8)). The high-risk group was independently associated with survival in a multivariate analysis that included conventional clinicopathological variables (P = 0.0060). We identified 14 candidate SNPs in 6 cancer-related genes, which were associated with poor survival in patients with metastatic PCa. A panel of SNPs may help predict the survival of those patients.

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