Role of Sirtuins in Stem Cell Differentiation | Zendy

Ramón María Alvargonzález Rodríguez | Zendy; Agustín F. Fernández | Zendy; Mario F. Fraga | Zendy

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Role of Sirtuins in Stem Cell Differentiation

Author(s) -

Ramón María Alvargonzález Rodríguez,

Agustín F. Fernández,

Mario F. Fraga

Publication year - 2013

Publication title -

genes and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.883

H-Index - 71

eISSN - 1947-6027

pISSN - 1947-6019

DOI - 10.1177/1947601913479798

Subject(s) - stem cell , telomere , senescence , cellular senescence , microbiology and biotechnology , cell cycle checkpoint , cell cycle , dna repair , medicine , cell , apoptosis , biology , dna damage , neuroscience , bioinformatics , genetics , dna , gene , phenotype

Sirtuins play an essential role in the cellular response to environmental stress, promoting DNA repair, telomere stability, cell cycle arrest, cellular senescence, and apoptosis. Much attention has been given to the role of sirtuins in aging and cancer development; however, less is known about their role in stem cell regulation. This review focuses in this topic and discusses the possible implications in adult stem cell aging.

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