Diverse Roles for the Paxillin Family of Proteins in Cancer | Zendy

Nicholas O. Deakin | Zendy; Jeanine Pignatelli | Zendy; Christopher E. Turner | Zendy

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Diverse Roles for the Paxillin Family of Proteins in Cancer

Author(s) -

Nicholas O. Deakin,

Jeanine Pignatelli,

Christopher E. Turner

Publication year - 2012

Publication title -

genes and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.883

H-Index - 71

eISSN - 1947-6027

pISSN - 1947-6019

DOI - 10.1177/1947601912458582

Subject(s) - paxillin , metastasis , carcinogenesis , scaffold protein , cancer , protein family , cancer cell , biology , cancer research , cell migration , microbiology and biotechnology , computational biology , bioinformatics , medicine , cell , signal transduction , focal adhesion , genetics , gene

The paxillin family of intracellular scaffold proteins includes paxillin, Hic-5, and leupaxin, and all have been identified as key regulators of the cellular migration machinery in both 2- and 3-dimensional microenvironments. Herein, we provide insight into the roles of these proteins during tumorigenesis and metastasis, highlighting their functions in cancer initiation as well as tumor cell dissemination and survival. Furthermore, we speculate on the potential of paxillin family proteins as both future prognostic and therapeutic targets.

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