From Hen House to Bedside: Tracing Hanafusa's Legacy from Avian Leukemia Viruses to SRC to ABL and Beyond | Zendy

Michael G. Kharas | Zendy; George Q. Daley | Zendy

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From Hen House to Bedside: Tracing Hanafusa's Legacy from Avian Leukemia Viruses to SRC to ABL and Beyond

Author(s) -

Michael G. Kharas,

George Q. Daley

Publication year - 2010

Publication title -

genes and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.883

H-Index - 71

eISSN - 1947-6027

pISSN - 1947-6019

DOI - 10.1177/1947601911407327

Subject(s) - proto oncogene tyrosine protein kinase src , tyrosine kinase , dasatinib , medicine , cancer , cancer research , oncogene , abl , leukemia , signal transduction , biology , immunology , genetics , cell cycle

The discovery of the Src oncogene was the first step on a long journey toward improved cancer chemotherapy. In this review, we explore Src and BCR-ABL, signal transduction, and recent advances in oncogene addiction and celebrate Hidesaboro Hanafusa and the many researchers who ushered in the age of target-directed therapy against tyrosine kinase oncoproteins.

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