Open AccessRegulation of ATM/DNA-PKcs Phosphorylation by BRCA1-Associated BAAT1
Author(s) -
Motoshi Ouchi,
Takeshi Ouchi
Publication year - 2010
Publication title -
genes and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.883
H-Index - 71
eISSN - 1947-6027
pISSN - 1947-6019
DOI - 10.1177/1947601911404222
Subject(s) - dna pkcs , dna damage , phosphorylation , dna , microbiology and biotechnology , dna repair , g2 m dna damage checkpoint , gene knockdown , kinase , biology , chemistry , protein kinase a , cancer research , genetics , gene , cell cycle checkpoint , cell cycle
BRCA1 has been implicated in the DNA damage pathway and regulation of genome stability, however, it does not contain intrinsic catalytic activity to repair the DNA lesions. Thus, a potential activity of BRCA1 is to assemble proteins that sense DNA damage and to transduce checkpoint signals to downstream. We have recently isolated a protein termed BAAT1, which binds to BRCA1, ATM, DNA-PKcs, and SMC1. Phosphorylation of ATM/DNA-PKcs is greatly reduced in BAAT1-knockdown cells, suggesting that sensing of DNA lesions mediated by BRCA1/BAAT1 is critical for activation of these kinases.
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