Open AccessAn Active Compound From Pseudomonas aeruginosa B27
Author(s) -
Xi Zheng,
Zixian Qin,
Jialei Kang,
Chunping Wan,
Guohong Li,
Xin Wang
Publication year - 2022
Publication title -
natural product communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.221
H-Index - 44
eISSN - 1934-578X
pISSN - 1555-9475
DOI - 10.1177/1934578x221086897
Subject(s) - bacillus subtilis , bacillus cereus , bacillus megaterium , chemistry , gallic acid , antibacterial activity , pseudomonas aeruginosa , stereochemistry , microbiology and biotechnology , nuclear chemistry , biochemistry , bacteria , antioxidant , biology , genetics
A compound was isolated from the fermented broth of Pseudomonas aeruginosa. The compound was determined as acridine-4-carboxylic acid based on nuclear magnetic resonance, mass spectrometry (MS), and single-crystal x-ray diffraction analysis. Acridine-4-carboxylic acid showed significant antibacterial activities against Staphylococcus aureus, Bacillus cereus, Bacillus subtilis, Bacillus megaterium, and Shinella sp. Moreover, the compound showed certain antitumor activities against HCT116, ST486, HCC1806, and A549 with IC 50 values of 38.38, 6.59, 20.69, and 82.81 μg/mL, respectively. In the test of nematicidal activity, acridine-4-carboxylic acid showed certain nematicidal activity against Caenorhabditis elegans and Meloidogyne incognita. In addition, the compound also exhibited 1,1-diphenyl-2-picrylhydrazyl free radical scavenging activity. Therefore, this compound may be used as a potential antibacterial, antitumor, nematicidal, and antioxidative agent.