Open Access4-(Dimethylamino)pyridine as an Efficient Catalyst for One-Pot Synthesis of 1,4-Pyranonaphthoquinone Derivatives viaMicrowave-Assisted Sequential Three Component Reaction in Green Solvent
Author(s) -
Nguyễn Hà Thành,
Hoàng Thị Phương,
Le Nhat Thuy Giang,
Nguyen Thi Quynh Giang,
Nguyễn Thị Thu Hà,
Đang Thi Tuyet Anh,
Vu Duc Cuong,
Nguyen Van Tuyen,
Phan Văn Kiệm
Publication year - 2021
Publication title -
natural product communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.221
H-Index - 44
eISSN - 1934-578X
pISSN - 1555-9475
DOI - 10.1177/1934578x211053951
Subject(s) - malononitrile , chemistry , yield (engineering) , catalysis , pyridine , combinatorial chemistry , organic chemistry , solvent , component (thermodynamics) , ethanol , materials science , physics , metallurgy , thermodynamics
Novel 1,4-pyranonaphthoquinone derivatives were successfully synthesized via the microwave-assisted three-component reaction of 1,4-naphthoquinone, malononitrile, and various arylaldehydes in ethanol in the presence of 4-(dimethylamino)pyridine (DMAP) as a catalyst, and subsequently evaluated in terms of their antimicrobial and antifungal activities. This synthetic procedure has the notable advantages of environmental friendliness, short reaction time, good yield, and convenient operation.