Open AccessThree Sulfur-Containing Natural Products From Rubus Hirsutus Thunb
Author(s) -
Na Lin,
Sihui Li,
Xuexia Chen,
Jiaojiao Song,
Yichao Ge,
Xiaodan Wu,
Huifang Zhang,
Bin Wu
Publication year - 2021
Publication title -
natural product communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.221
H-Index - 44
eISSN - 1934-578X
pISSN - 1555-9475
DOI - 10.1177/1934578x211011383
Subject(s) - rubus , chemistry , circular dichroism , mass spectrometry , staphylococcus aureus , nuclear magnetic resonance spectroscopy , sulfur , stereochemistry , organic chemistry , botany , bacteria , chromatography , biology , genetics
Chemical investigation of the leaves and stems of Rubus hirsutus Thunb has resulted in the isolation and characterization of a rare new tricyclic thienocyclopentapyran (1) and 2 known thiophenes, 5-(3-buten-1-ynul)−2,2’-bithiophene (2) and α-terthienyl (3). The structure of compound 1 was unambiguously determined by nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry and time-dependent density functional theory electronic circular dichroism calculations. The new compound 1 exhibited impressive antibiotic properties against methicillin resistant Staphylococcus aureus (MRSA), with an MIC value of around 1 µg/mL.