Open AccessChemical Constituents of the Whole Plant of Verbena hastata and Their Inhibitory Activity Against the Production of AGEs
Author(s) -
Akihito Yokosuka,
M. Honda,
Hitoshi Kondo,
Yoshihiro Mimaki
Publication year - 2021
Publication title -
natural product communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.221
H-Index - 44
eISSN - 1934-578X
pISSN - 1555-9475
DOI - 10.1177/1934578x211009727
Subject(s) - glycoside , chemistry , verbenaceae , terpene , stereochemistry , biflavonoids , botany , biology
Two iridoid glycosides (1 and 2), 3 phenolic glycosides (3–5), 1 flavone glycoside (6), 3 biflavonoids (7–9), 1 flavone (10), 2 triterpenes (11 and 12), 1 sterol (13), and 1 naphthoquinone derivative (14) were isolated from the whole plant of Verbena hastata (Verbenaceae). Compounds 3-13 were isolated from V. hastata for the first time. Compound 14 is undescribed in the literature. Incubation of glyceraldehyde and collagen either with phenolic glycosides (3), (4), or (5) or with biflavonoid (8) inhibited the production of advanced glycation end products, with IC 50 values of 6.3, 6.4, 6.2, and 6.8 mM, respectively. Aminoguanidine, which was used as a positive control, had an IC 50 value of 10.2 mM.