Open AccessTHE SIGNIFICANCE OF MUCOPOLYSACCHARIDES IN AMYLOID
Author(s) -
Mordechai Pras,
Zvi Nevo,
Jossie Rotman,
Maxwell Schubert,
Reuben Matalon
Publication year - 1971
Publication title -
journal of histochemistry and cytochemistry/the journal of histochemistry and cytochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.971
H-Index - 124
eISSN - 1551-5044
pISSN - 0022-1554
DOI - 10.1177/19.7.443
Subject(s) - amyloid (mycology) , amyloidosis , glycosaminoglycan , familial mediterranean fever , pathology , chemistry , amyloid disease , rheumatoid arthritis , serum amyloid a , amyloid fibril , medicine , biochemistry , disease , immunology , amyloid β , inflammation
Amyloid was extracted from six amyloid-laden organs of four different diseases: familial Mediterranean fever (FMF), Hodgkin's disease, rheumatoid arthritis and tuberculosis. In the case of FMF amyloid extracts of three different organs of the same patient were prepared. Chemical studies have indicated the identity of the mucopolysaccharide composition in the amyloid preparations, the amyloid-laden organs and normal organs. The differences were limited to the amounts of the mucopolysaccharide components. The metachromatic properties of an amyloid preparations were not directly related to the level of mucopolysaccharides present. The protein of the amyloid fibers was found to differ chemically from the core protein of chondromucoprotein.