CYTOCHEMICAL LOCALIZATION OF CHOLINESTERASE ACTIVITY IN ADULT RABBIT HEART | Zendy

Martin Hagopian | Zendy; Virginia M. Tennyson | Zendy

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CYTOCHEMICAL LOCALIZATION OF CHOLINESTERASE ACTIVITY IN ADULT RABBIT HEART

Author(s) -

Martin Hagopian,

Virginia M. Tennyson

Publication year - 1971

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/19.6.376

Subject(s) - cholinesterase , acetylcholinesterase , butyrylcholinesterase , endoplasmic reticulum , chemistry , rabbit (cipher) , aché , medicine , anatomy , enzyme , biology , biochemistry , endocrinology , statistics , mathematics

The papillary muscle of the adult rabbit heart was studied by a modification of the Koelle-Friedenwald copper thiocholine technique for the localization of cholinesterase activity. Butyrylcholinesterase (BuChE), identified by its substrate and inhibitor specificity, is found mainly in the terminal sacs of the sarcoplasmic reticulum adjacent to the T system. The localization of the reaction product in this particular site suggests that BuChE may play a role in excitation-contraction coupling in the adult rabbit heart. The present findings are also discussed in comparison with our previous work on the localization of acetylcholinesterase activity in the embryonic rabbit heart.

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