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The uptake of proteins in rabbit synovial membrane was studied with the peroxidase tracer technique. The morphologic characteristics of the synovial cells formed a continuum from those of type "A" to those of type "B." Cells in which type A characteristics predominated took up large amounts of protein, both by a process of bulk incorporation and by pinocytosis. Pinocytosis of smaller amounts of protein occurred in cells with characteristics of type B. Bulk incorporation in cells with type A characteristics increased with increasing molecular size of the protein tracer. Differential uptake of proteins by synovial cells may be important in determining the protein composition of synovial fluid.

PROTEIN UPTAKE BY SYNOVIAL CELLS I. ULTRASTRUCTURAL STUDY OF THE FATE OF INTRAARTICULARLY INJECTED PEROXIDASES