PROTEIN UPTAKE BY SYNOVIAL CELLS I. ULTRASTRUCTURAL STUDY OF THE FATE OF INTRAARTICULARLY INJECTED PEROXIDASES | Zendy

Sarajayne Limpert Shan | Zendy; Richard C. Graham | Zendy

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PROTEIN UPTAKE BY SYNOVIAL CELLS I. ULTRASTRUCTURAL STUDY OF THE FATE OF INTRAARTICULARLY INJECTED PEROXIDASES

Author(s) -

Sarajayne Limpert Shan,

Richard C. Graham

Publication year - 1971

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/19.1.29

Subject(s) - pinocytosis , peroxidase , ultrastructure , chemistry , synovial membrane , synovial fluid , horseradish peroxidase , biophysics , microbiology and biotechnology , biology , biochemistry , pathology , anatomy , cell , enzyme , endocytosis , inflammation , immunology , medicine , osteoarthritis , alternative medicine

The uptake of proteins in rabbit synovial membrane was studied with the peroxidase tracer technique. The morphologic characteristics of the synovial cells formed a continuum from those of type "A" to those of type "B." Cells in which type A characteristics predominated took up large amounts of protein, both by a process of bulk incorporation and by pinocytosis. Pinocytosis of smaller amounts of protein occurred in cells with characteristics of type B. Bulk incorporation in cells with type A characteristics increased with increasing molecular size of the protein tracer. Differential uptake of proteins by synovial cells may be important in determining the protein composition of synovial fluid.

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