Open AccessPrecision diagnostics of Ewing’s sarcoma by liquid biopsy: circulating EWS-FLI1 fusion transcripts
Author(s) -
Matteo Allegretti,
Beatrice Casini,
Chiara Mandoj,
Stefania Benini,
Laurent Alberti,
Mariangela Novello,
Elisa Melucci,
Laura Conti,
Renato Covello,
Edoardo Pescarmona,
Giuseppe Maria Milano,
Alessio Annovazzi,
Vincenzo Anelli,
Virginia Ferraresi,
R. Biagini,
Patrizio Giacomini
Publication year - 2018
Publication title -
therapeutic advances in medical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 49
eISSN - 1758-8359
pISSN - 1758-8340
DOI - 10.1177/1758835918774337
Subject(s) - medicine , ewing's sarcoma , sarcoma , biopsy , fli1 , cancer research , fusion gene , pathology , radiology , oncology , chromosomal translocation , biology , gene , biochemistry
To our knowledge, this is one of the few single-marker LB assays in solid tumors specifically designed to detect rearranged RNAs in blood, and the first study describing circulating tumor RNAs in ES patients. Altogether, our results support the idea that LB may have a considerable impact on ES patient monitoring and management.
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