Edaravone, a potent free radical scavenger and a calcium channel blocker attenuate isoproterenol induced myocardial infarction by suppressing oxidative stress, apoptotic signaling and ultrastructural damage | Zendy

Md Quamrul Hassan | Zendy; Md Sayeed Akhtar | Zendy; Mohd Akhtar | Zendy; Javed Ali | Zendy; Syed Ehtaishamul Haque | Zendy; Abul Kalam Najmi | Zendy

Open Access

Edaravone, a potent free radical scavenger and a calcium channel blocker attenuate isoproterenol induced myocardial infarction by suppressing oxidative stress, apoptotic signaling and ultrastructural damage

Author(s) -

Md Quamrul Hassan,

Md Sayeed Akhtar,

Mohd Akhtar,

Javed Ali,

Syed Ehtaishamul Haque,

Abul Kalam Najmi

Publication year - 2016

Publication title -

therapeutic advances in cardiovascular disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.164

H-Index - 33

eISSN - 1753-9455

pISSN - 1753-9447

DOI - 10.1177/1753944716630653

Subject(s) - edaravone , free radical scavenger , malondialdehyde , pharmacology , oxidative stress , medicine , glutathione peroxidase , superoxide dismutase , lactate dehydrogenase , glutathione , antioxidant , tunel assay , glutathione reductase , creatine kinase , catalase , chemistry , biochemistry , immunohistochemistry , enzyme

In the present study, we investigated whether combination therapy of low-dose benidipine with the potent free radical scavenger edaravone has a cardioprotective effect against isoproterenol (ISO)-induced myocardial infarction (MI) in Wistar rats.

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