Expression of genes of the cardiac and renal renin–angiotensin systems in preterm piglets: is this system a suitable target for therapeutic intervention? | Zendy

Eleanor Kim | Zendy; Yvonne A. Eiby | Zendy; Eugenie R. Lumbers | Zendy; A Boyce | Zendy; Karen J. Gibson | Zendy; Barbara E. Lingwood | Zendy

Open Access

Expression of genes of the cardiac and renal renin–angiotensin systems in preterm piglets: is this system a suitable target for therapeutic intervention?

Author(s) -

Eleanor Kim,

Yvonne A. Eiby,

Eugenie R. Lumbers,

A Boyce,

Karen J. Gibson,

Barbara E. Lingwood

Publication year - 2015

Publication title -

therapeutic advances in cardiovascular disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.164

H-Index - 33

eISSN - 1753-9455

pISSN - 1753-9447

DOI - 10.1177/1753944715578615

Subject(s) - renin–angiotensin system , medicine , kidney , endocrinology , angiotensin ii , plasma renin activity , messenger rna , angiotensin converting enzyme 2 , angiotensin ii receptor type 1 , blood pressure , biology , gene , biochemistry , disease , covid-19 , infectious disease (medical specialty)

The newborn circulating, cardiac and renal renin-angiotensin systems (RASs) are essential for blood pressure control, and for cardiac and renal development. If cardiac and renal RASs are immature this may contribute to cardiovascular compromise in preterm infants. This study measured mRNA expression of cardiac and renal RAS components in preterm, glucocorticoid (GC) exposed preterm, and term piglets.

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