Review: Therapeutic potential of plasminogen activator inhibitor-1 inhibitors | Zendy

Nancy J. Brown | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Review: Therapeutic potential of plasminogen activator inhibitor-1 inhibitors

Author(s) -

Nancy J. Brown

Publication year - 2010

Publication title -

therapeutic advances in cardiovascular disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.164

H-Index - 33

eISSN - 1753-9455

pISSN - 1753-9447

DOI - 10.1177/1753944710379126

Subject(s) - medicine , plasminogen activator inhibitor 1 , fibrinolysis , plasminogen activator , pathogenesis , pharmacology , tissue plasminogen activator , cancer research , thrombosis , immunology

Plasminogen activator inhibitor-1 (PAI-1) is the major physiological inhibitor of fibrinolysis and regulates cell migration and fibrosis. Preclinical studies using genetically altered mice and biological or small molecule inhibitors have elucidated a role for PAI-1 in the pathogenesis of thrombosis, vascular remodeling, renal injury, and initiation of diabetes. Inhibition of PAI-1 is a potential therapeutic strategy in these diseases.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research