Advances in proton therapy in lung cancer | Zendy

Melissa A.L. Vyfhuis | Zendy; N. Onyeuku | Zendy; Tejan Diwanji | Zendy; Sina Mossahebi | Zendy; Neha P. Amin | Zendy; Shahed N. Badiyan | Zendy; Pranshu Mohindra | Zendy; Charles B. Simone | Zendy

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Advances in proton therapy in lung cancer

Author(s) -

Melissa A.L. Vyfhuis,

N. Onyeuku,

Tejan Diwanji,

Sina Mossahebi,

Neha P. Amin,

Shahed N. Badiyan,

Pranshu Mohindra,

Charles B. Simone

Publication year - 2018

Publication title -

therapeutic advances in respiratory disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.022

H-Index - 37

eISSN - 1753-4666

pISSN - 1753-4658

DOI - 10.1177/1753466618783878

Subject(s) - medicine , lung cancer , proton therapy , radiation therapy , cancer , lung , stage (stratigraphy) , esophagus , oncology , population , intensive care medicine , paleontology , environmental health , biology

Lung cancer remains the leading cause of cancer deaths in the United States (US) and worldwide. Radiation therapy is a mainstay in the treatment of locally advanced non-small cell lung cancer (NSCLC) and serves as an excellent alternative for early stage patients who are medically inoperable or who decline surgery. Proton therapy has been shown to offer a significant dosimetric advantage in NSCLC patients over photon therapy, with a decrease in dose to vital organs at risk (OARs) including the heart, lungs and esophagus. This in turn, can lead to a decrease in acute and late toxicities in a population already predisposed to lung and cardiac injury. Here, we present a review on proton treatment techniques, studies, clinical outcomes and toxicities associated with treating both early stage and locally advanced NSCLC.

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