From large clinical trials to management of COPD in the real world | Zendy

Mario Cazzola | Zendy

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From large clinical trials to management of COPD in the real world

Author(s) -

Mario Cazzola

Publication year - 2009

Publication title -

therapeutic advances in respiratory disease

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.022

H-Index - 37

eISSN - 1753-4666

pISSN - 1753-4658

DOI - 10.1177/1753465809102381

Subject(s) - medicine , copd , exacerbation , pulmonary disease , clinical trial , intensive care medicine , quality of life (healthcare) , clinical endpoint , physical therapy , nursing

Large clinical trials in chronic obstructive pulmonary disease (COPD) are analyzed and discussed. Unfortunately, all of them have failed to reach their primary endpoint, which has mainly been the effect on the rate of decline in mean FEV 1 (forced expiratory volume in 1 second). Nonetheless, almost all trials have demonstrated benefits in important outcomes such as exacerbation frequency, symptoms, quality of life and other measures of health status, which are arguably more meaningful to individual patients than FEV 1 per se.

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