Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro | Zendy

Emmanuel C. Patin | Zendy; Sam Willcocks | Zendy; Selinda J. Orr | Zendy; Theresa H. Ward | Zendy; Roland Lang | Zendy; Ulrich E. Schaible | Zendy

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Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro

Author(s) -

Emmanuel C. Patin,

Sam Willcocks,

Selinda J. Orr,

Theresa H. Ward,

Roland Lang,

Ulrich E. Schaible

Publication year - 2016

Publication title -

innate immunity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.921

H-Index - 69

eISSN - 1753-4267

pISSN - 1753-4259

DOI - 10.1177/1753425916636671

Subject(s) - secretion , macrophage , in vitro , inflammation , anti inflammatory , microbiology and biotechnology , inflammatory response , interleukin 10 , lectin , immunology , chemistry , biology , immune system , biochemistry

The role of macrophage-inducible C-type lectin (Mincle) in anti-inflammatory responses has not yet been fully characterized. Herein, we show that engagement of Mincle by trehalose-dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-regulation of IL-12p40 secretion. Thus, Mincle mediates both pro- as well as anti-inflammatory responses.

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