Open AccessThe association of bariatric surgery and Dupuytren’s disease: a propensity score-matched cohort study
Author(s) -
Theresa Burkard,
Jennifer C E Lane,
Dag Holmberg,
Anders Thorell,
Andrea M. Burden,
Dominic Furniss
Publication year - 2021
Publication title -
journal of hand surgery. european volume
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.104
H-Index - 79
eISSN - 2043-6289
pISSN - 1753-1934
DOI - 10.1177/17531934211062023
Subject(s) - medicine , hazard ratio , propensity score matching , surgery , cohort study , confidence interval , cohort , proportional hazards model , obesity
We aimed to assess the association between bariatric surgery and incident Dupuytren’s disease (DD) using propensity score-matched cohort studies among Swedish nationwide healthcare registries. Patients aged 30–79 years who underwent bariatric surgery 2006–2019 were matched on their propensity scores, up to two obese bariatric surgery-free (unexposed) patients. We applied Cox proportional hazard regression to calculate hazard ratios (HR) with 95% confidence intervals (CI) for the risk of DD overall, in subgroups of age, sex, bariatric surgery type and duration of follow-up. Among 34,959 bariatric surgery patients and 54,769 propensity score-matched obese patients, the risk of DD was increased in bariatric surgery patients compared with obese unexposed patients (HR 1.30, 95% CI 1.02–1.65), among women (HR 1.36; 1.00–1.84); those undergoing gastric bypass (HR 1.33; 1.04–1.71) and those with >5 years follow-up (HR 1.63; 1.14–2.34). Our results suggest that substantial weight loss is associated with an increased risk of DD in an obese population. Level of evidence: III