Infective endocarditis and mannose-binding lectin deficiency – A case report | Zendy

Ximena Watson | Zendy; Mike Parris | Zendy

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Infective endocarditis and mannose-binding lectin deficiency – A case report

Author(s) -

Ximena Watson,

Mike Parris

Publication year - 2015

Publication title -

journal of the intensive care society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.551

H-Index - 14

eISSN - 2057-360X

pISSN - 1751-1437

DOI - 10.1177/1751143715581392

Subject(s) - mannan binding lectin , medicine , endocarditis , pneumonia , lectin , meningitis , infective endocarditis , immunology , intensive care medicine , microbiology and biotechnology , pediatrics , biology

We present the case of a 40-year-old woman diagnosed with Austrian syndrome, an association of endocarditis, meningitis and pneumonia caused by Streptococcus pneumonia. She had none of the risk factors previously described in the literature but on immunological assay was found to have low serum levels of mannose-binding lectin, a protein required for complement activation. The clinical manifestation and treatment of this condition are discussed, and we emphasize the importance of early recognition of cardiac involvement and prompt surgical management.

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